Ivet Bahar, Ph.D. (PI of CDAR, and Core B Leader)
Distinguished Professor and John K. Vries Chair
Department of Computational & Systems Biology
School of Medicine, University of Pittsburgh
Website

 

 

ChengHongying Cheng, PhD, Res Assistant Professor (Core B Co-Leader)
Dept. of Computational & Systems Biology, Pitt.
Mary’s research interest and expertise lie in protein modeling and medicinal chemistry, with focus on molecular mechanism of (i) transporter function, (ii) drug modulation (iii) ion transport through membrane protein channels and (iv) protein-lipid and lipid-lipid interactions. Her current research focusses on understanding these aspects on of Neurotransmitter sodium symporter (NSS) family of proteins.

 

LiuBing Liu, PhD, Res Assistant Professor
Dept. of Computational & Systems Biology, Pitt.
Bing Liu’s research area centers on computational systems biology. His work builds mathematical models to describe the dynamics of biological processes. He has developed probabilistic techniques to address stochasticity in biological systems and leveraged machine learning, formal methods, and high-performance computing techniques to enable various analyses of large-scale systems.

 

LiHongChun Li, PhD, Postdoctoral Associate
Dept. of Computational & Systems Biology, Pitt.
Hongchun Li’s research interests: Interactions between antimicrobial peptides and membranes; thermostability of proteins; online services for elastic network models (e.g. Gaussian network model, anisotropic network model and intrinsic dynamic domains); prediction of drug-target interactions based on probabilistic matrix factorization.

 

LeeJi Young Lee, PhD, Research Associate
Dept. of Computational & Systems Biology, Pitt.
Ji Young is using normal mode analysis and molecular dynamics simulations to provide insights into the activation/inactivation mechanism of target proteins. As one of his studies, he has been studying ionotropic glutamate receptors (iGluRs) which are ion channels mediating excitatory neurotransmission. Using Anisotropic Network Model (ANM) calculations, he has found that two prominent subfamily members of iGluRs, AMPA receptor (AMPAR) and NMDA receptor (NMDAR), share robust movements.

 

Karolina Mikulska-Ruminska, PhD, Postdoctoral Associate
Dept. of Computational & Systems Biology, Pitt.
Research Interests: Molecular dynamics and steered molecular dynamics methods (all-atom and coarse-grained), protein-ligand docking, bioinformatic analysis, single molecule force spectroscopy (AFM), homology modeling, drug design.

 

 

James Krieger, PhD, Postdoctoral Associate
Dept. of Computational & Systems Biology, Pitt.
Research Interests: Structural biology and bioinformatics; protein dynamics and signaling.

 

 

 

Cihan Kaya, PhD Student
Dept. of Computational & Systems Biology, Pitt.
Research Interests: Multiscale modeling of biological systems.

 

 

 

ZhangShe (John) Zhang, PhD Student
Dept. of Computational & Systems Biology, Pitt.
John is currently working on applying elastic network models to several proteins including NSS family and HIV-RT to determine their principal motions and associate these to their respective biological functions.

 

 

Yan Zhang, PhD Student
Dept. of Computational & Systems Biology, Pitt.
Research Interests: Mesoscale modeling of biological systems.